Fmoc-D-Trp(Boc)-CTC Resin
Fmoc-D-Trp(Boc) -2-Chlorotrityl chloride resin
2-Chlorotrityl Chloride (2-CTC) Resin – Mildly Acid-Labile Solid Support
2-Chlorotrityl Chloride (2-CTC) Resin is a polystyrene-based resin functionalized with a 2-chlorotrityl chloride linker, widely used in Fmoc solid-phase peptide synthesis (SPPS). Its mild acid-labile linker allows for gentle cleavage of peptides while preserving side-chain protection, making it ideal for protected peptide intermediates, fragment condensation, and peptide libraries.
Product | Fmoc-D-Trp(Boc)-CTC Resin |
Catalog No. | PR3034 |
Cas no. | NA |
Matrix/Backbone: | Polystyrene crosslinked with 1% DVB |
Degree of cross-linking (% DVB) | 1% |
Substitution (mmol/g) | 0.6 - 1.2 mmol/g |
Mesh Size | 100 - 200 |
Apperance | Pale or slight yellow beads |
Loss on drying (%) | ≤ 2.0 |
Degree of swelling in DCM (ml/g) | 5.0 - 9.0 |
Degree of swelling in DMF (ml/g) | 4.0 - 8.0 |
Storage | 02 - 04 |
Cleavage & Applications
Cleavage Conditions:
Mild cleavage: 1–2% TFA in DCM → releases protected peptide fragments
Strong cleavage: Standard TFA cocktail (TFA/TIS/H₂O) → fully deprotected peptide with C-terminal carboxylic acid
Applications:
Synthesis of fragment peptides for segment condensation
Generation of protected peptide intermediates
Ideal for peptide libraries and combinatorial chemistry
Key Advantages
Mild acid-labile linker preserves sensitive protecting groups
Tunable loading suitable for long or difficult sequences
Excellent swelling for efficient coupling
Widely used for fragment-based and combinatorial SPPS
Storage & Handling
Store at 2–8 °C under dry conditions
Protect from moisture and air
Pre-swell in DMF or DCM before use
Size | Price | Discount | Global stock |
5 g | Enquiry | NA | In-stock |
25 g | Enquiry | NA | In-stock |
100 g | Enquiry | NA | In-stock |
others | Enquiry | NA | In-stock |
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